Palladium-Catalyzed C–H Ethoxycarbonyldifluoromethylation of Electron-Rich Heteroarenes

array(2) { ["lab"]=> string(3) "361" ["publication"]=> string(4) "4709" } Palladium-Catalyzed C–H Ethoxycarbonyldifluoromethylation of Electron-Rich Heteroarenes - 张扬会课题组 | LabXing

张扬会课题组

简介

关注

2015

期刊 Organic Letters

作者 Changdong Shao · Guangfa Shi · Yanghui Zhang · Shulei Pan · Xiaohong Guan

下载全文阅读全文

The first Pd-catalyzed C–H ethoxycarbonyldifluoromethylation with BrCF2CO2Et has been developed. The use of a bidentate phosphine ligand (Xantphos) is critical for the reaction to occur. A variety of electron-rich heteroarenes, including indoles, furans, thiophenes, and pyrroles, can be ethoxycarbonyldifluoromethylated in moderate to excellent yields. The reactions take place at the C–H bonds adjacent to the heteroatoms with high regioselectivity. This method provides a new protocol for the introduction of difuoroalkyl groups into electron-rich heteroarenes.

卷 17
期 11
页码 2652-2655
American Chemical Society (ACS)
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.5b01024

LabXing 上可以免费创建课题组网站