A Versatile Approach for the Synthesis of para-Substituted Arenes via Palladium-Catalyzed C–H Functionalization and Protodecarboxylation of Benzoic Acids

array(2) { ["lab"]=> string(3) "361" ["publication"]=> string(4) "4710" } A Versatile Approach for the Synthesis of para-Substituted Arenes via Palladium-Catalyzed C–H Functionalization and Protodecarboxylation of Benzoic Acids - 张扬会课题组 | LabXing

张扬会课题组

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2016

期刊 Synlett

作者 Yanghui Zhang · Shulei Pan · Bo Zhou · Changdong Shao · Guangfa Shi

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While a great number of ortho C–H functionalization reactions have been developed and several breakthroughs have been achieved in meta C–H activation, para C–H functionalization is still in its infancy stage. In this article, a versatile strategy for the synthesis of para-substituted arenes has been developed via a tandem process consisting of palladium-catalyzed C–H functionalization and subsequent copper-catalyzed protodecarboxylation of benzoic acids. Both electron-withdrawing and electron-donating functionalities can be introduced into the para positions of arenes bearing a variety of substituents.

卷 27
期 02
页码 277-281
Georg Thieme Verlag KG
ISSN: 0936-5214
DOI: 10.1055/s-0035-1560579

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