Synthesis of Fluorenes Starting from 2-Iodobiphenyls and CH2Br2 through Palladium-Catalyzed Dual C–C Bond Formation

array(2) { ["lab"]=> string(3) "361" ["publication"]=> string(4) "4716" } Synthesis of Fluorenes Starting from 2-Iodobiphenyls and CH2Br2 through Palladium-Catalyzed Dual C–C Bond Formation - 张扬会课题组 | LabXing

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2016

期刊 Organic Letters

作者 Guangfa Shi · Dushen Chen · Hang Jiang · Yu Zhang · Yanghui Zhang

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A facile and efficient approach is developed for the synthesis of fluorene and its derivatives starting from 2-iodobiphenyls and CH2Br2. A range of fluorene derivatives can be synthesized under relatively mild conditions. The reaction proceeds via a tandem palladium-catalyzed dual C–C bond formation sequence through the key dibenzopalladacyclopentadiene intermediates, which are obtained from 2-iodobiphenyls through palladium-catalyzed C–H activation.

卷 18
期 12
页码 2958-2961
American Chemical Society (ACS)
ISSN: 1523-7060
DOI: 10.1021/acs.orglett.6b01300

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