array(2) { ["lab"]=> string(3) "361" ["publication"]=> string(4) "4727" } Pd(II)-Catalyzed Catellani-Type Domino Reaction Utilizing Arylboronic Acids as Substrates - 张扬会课题组 | LabXing

张扬会课题组

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大学 同济大学 / 化学科学与工程学院
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Pd(II)-Catalyzed Catellani-Type Domino Reaction Utilizing Arylboronic Acids as Substrates

2018
期刊 ACS Catalysis
The Catellani reaction provides a facile and efficient method for the synthesis of multifunctionalized arenes. However, the use of Pd(0) catalysts restricts the scope of accessible products. We have developed a Pd(II)-catalyzed, Catellani-type reaction utilizing arylboronic acids as the substrates for the first time. The arylboronic acids can be mono- or dialkylated at the ortho positions with alkyl iodides and olefinated at the ipso positions with olefins, producing various multifunctionalized aromatic compounds. This work should open new avenues for developing novel Catellani reactions, in particular those using new electrophiles.

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