The same RNA molecular can fold into different secondary structure, especially when the folding is interfered by different trans-regulatory factors met at different stages of its life. E.g., during transcription, template DNA strand might competitively inhibit RNA folding; During translation, ribosomes might preclude certain fragments of mRNA from folding. We assessed the specificity and function of such differential foldings using high-throughput sequencing data of RNA secondary structures.
系统与进化基因组学实验室
研究随机现象如何影响生物的功能与进化
Secondary structure of an RNA at different stages of its life
创建: Jan 21, 2019 | 13:44