Complement Factor H Displays Opposite Expression Patterns Under Two Situations of Methamphetamine Administration: Acute Exposure and Chronic Dependence - 新型多组学研究综合实验室（王晓东课题组）

Dear Editor,Methamphetamine(METH)is a highly addictive central nervous system stimulant that has severe physical and psychological side-effects,including loss of appetite, hyperactivity, dysphoria, and depression[1].Due to its illegal production, distribution, sale, and possession it has become a worldwide burden.METH is directly toxic to dopaminergic and serotoninergic neurons, resulting in excitotoxicity,oxidative stress,and other processes[2].Research on biomolecules associated with these processes will be useful for identifying potential markers, exploring the mechanism of METH dependence, and even developing prevention and treatment strategies.