array(2) { ["lab"]=> string(3) "960" ["publication"]=> string(4) "7215" } Carboxylate-Assisted Pd(II)-Catalyzed ortho-C–H and Remote C–H Activation: Economical Synthesis of Pyrano[4,3-b]Indol-1(5H)-ones - zeng's paper | LabXing

zeng's paper

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大学 湖北大学 / 化学化工学院
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Carboxylate-Assisted Pd(II)-Catalyzed ortho-C–H and Remote C–H Activation: Economical Synthesis of Pyrano[4,3-b]Indol-1(5H)-ones

2019
期刊 Organic Letters
An original Pd(II)-catalyzed domino two C−H activations strategy has been designed to synthesize pyrano[4,3b]indol-1(5H)-one motifs from inexpensive and commercially available olefins and heteroaromatic acids by carboxylate-directed sequential ortho-C−H alkenylation and remote C−H lactonization. Importantly, this protocol overcomes the selectivity for carboxylic acids with acrylates of the conventional Michael addition-type process. Preliminary studies of mechanism indicate that both aryl and olefinlic C−H activations may participate in this catalytic system.

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