array(2) { ["lab"]=> string(3) "998" ["publication"]=> string(4) "7891" } Target Delivery of a Novel Antitumor Organoplatinum(IV) Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo - 郭伟实验室 | LabXing

郭伟实验室

简介 多功能纳米材料的制备及其光热转化性能研究

大学 哈尔滨师范大学 / 化学化工学院
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Target Delivery of a Novel Antitumor Organoplatinum(IV) Substituted Polyoxometalate Complex for Safer and More Effective Colorectal Cancer Therapy In Vivo

2016
期刊 Advacned Materials
An inactive organoplatinum(IV)‐substituted polyoxometalate is developed as an efficient and nontoxic prodrug with significant potential for treating human colorectal cancers. Further encapsulation of PtIV‐PW11 with DSPE‐PEG2000 nanoparticles (NPs) enables targeted delivery and controlled release of inactive prodrug. Such PtIV‐PW11‐DSPE‐PEG2000 NPs are highly efficient in inhibiting cellular growth of HT29 cells and treating human colorectal cancer in mice, superior to classic cisplatin.

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