Chen lab of Molecular and Genomic Evolution

Expression level is a major modifier of the fitness landscape of a protein coding gene

2021

期刊 Nature Ecology & Evolution 有全文

作者 Zhuoxing Wu · Xiujuan Cai · Xin Zhang · Yao Liu · Guo-Bao Tian · Jian-Rong Yang · Xiaoshu Chen

Transcriptome Analysis in Yeast Reveals the Externality of Position Effects

2021

期刊 Molecular Biology and Evolution 有全文

作者 Qian Gui · Shuyun Deng · Zhenzhen Zhou · Waifang Cao · Xin Zhang · Wenjun Shi · Xiujuan Cai · Wenbing Jiang · Zifeng Cui · Zheng Hu · Xiaoshu Chen

Bidirectional Genetic Control of Phenotypic Heterogeneity and Its Implication for Cancer Drug Resistance

2020

期刊 Molecular Biology and Evolution 有全文

作者 Ning Mo · Xiaoyu Zhang · Wenjun Shi · Gongwang Yu · Xiaoshu Chen · Jian-Rong Yang

Dissimilation of synonymous codon usage bias in virus–host coevolution due to translational selection

2020

期刊 Nature Ecology & Evolution 有全文

作者 Feng Chen · Peng Wu · Shuyun Deng · Heng Zhang · Yutong Hou · Zheng Hu · Jianzhi Zhang · Xiaoshu Chen · Jian-Rong Yang

The evolution of sex chromosome dosage compensation in animals

2020

期刊 Journal of Genetics and Genomics 有全文

作者 Jiabi Chen · Menghan Wang · Xionglei He · Jian-Rong Yang · Xiaoshu Chen

Dosage sensitivity of X-linked genes in human embryonic single cells

2019

期刊 BMC Genomics 有全文

作者 Jian-Rong Yang · Xiaoshu Chen

The Genomic Landscape of Position Effects on Protein Expression Level and Noise in Yeast

2016

期刊 Cell Systems 有全文

作者 Xiaoshu Chen · Jianzhi Zhang

The X to Autosome Expression Ratio in Haploid and Diploid Human Embryonic Stem Cells

2016

期刊 Molecular Biology and Evolution 有全文

作者 Xiaoshu Chen · Jianzhi Zhang

Nascent RNA folding mitigates transcription-associated mutagenesis

2015

期刊 Genome Research 有全文

作者 Xiaoshu Chen · Jian-Rong Yang · Jianzhi Zhang

No X-Chromosome Dosage Compensation in Human Proteomes

2015

期刊 Molecular Biology and Evolution 有全文

作者 Xiaoshu Chen · Jianzhi Zhang

Codon-by-Codon Modulation of Translational Speed and Accuracy Via mRNA Folding

2014

期刊 PLoS Biology 有全文

作者 Jian-Rong Yang · Xiaoshu Chen · Jianzhi Zhang

Yeast mutation accumulation experiment supports elevated mutation rates at highly transcribed sites

2014

期刊 Proceedings of the National Academy of Sciences 有全文

作者 Xiaoshu Chen · Jianzhi Zhang

Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly

2013

期刊 Proceedings of the National Academy of Sciences 有全文

作者 C. Park · X. Chen · J.-R. Yang · J. Zhang

No Gene-Specific Optimization of Mutation Rate in Escherichia coli

2013

期刊 Molecular Biology and Evolution 有全文

作者 X. Chen · J. Zhang

Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome?

2013

期刊 Genome Biology and Evolution 有全文

作者 X. Chen · J. Zhang

Nucleosomes Suppress Spontaneous Mutations Base-Specifically in Eukaryotes

2012

期刊 Science 有全文

作者 Xiaoshu Chen · Zhidong Chen · Han Chen · Zhijian Su · Jianfeng Yang · Fangqin Lin · Suhua Shi · Xionglei He

The Ortholog Conjecture Is Untestable by the Current Gene Ontology but Is Supported by RNA Sequencing Data

2012

期刊 PLoS Computational Biology 有全文

作者 Xiaoshu Chen · Jianzhi Zhang

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Expression level is a major modifier of the fitness landscape of a protein coding gene

Transcriptome Analysis in Yeast Reveals the Externality of Position Effects

Bidirectional Genetic Control of Phenotypic Heterogeneity and Its Implication for Cancer Drug Resistance

Dissimilation of synonymous codon usage bias in virus–host coevolution due to translational selection

The evolution of sex chromosome dosage compensation in animals

Dosage sensitivity of X-linked genes in human embryonic single cells

The Genomic Landscape of Position Effects on Protein Expression Level and Noise in Yeast

The X to Autosome Expression Ratio in Haploid and Diploid Human Embryonic Stem Cells

Nascent RNA folding mitigates transcription-associated mutagenesis

No X-Chromosome Dosage Compensation in Human Proteomes

Codon-by-Codon Modulation of Translational Speed and Accuracy Via mRNA Folding

Yeast mutation accumulation experiment supports elevated mutation rates at highly transcribed sites

Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly

No Gene-Specific Optimization of Mutation Rate in Escherichia coli

Why Are Genes Encoded on the Lagging Strand of the Bacterial Genome?

Nucleosomes Suppress Spontaneous Mutations Base-Specifically in Eukaryotes

The Ortholog Conjecture Is Untestable by the Current Gene Ontology but Is Supported by RNA Sequencing Data